Do you know about Site Specific Browsers (SSBs)? You should…they’re really useful.
A site-specific browser lets you turn a website into a standalone "app" that appears in the Dock and can be started and stopped independently of other browser instances running on your computer.
I first learned about these from the valuable TidBITS publication, and am so glad that I did.
I've purchased Coherence X4 to do this, but there are a number of other competing solutions. I've created a handful of SSB apps with Coherence, but the most valuable one for me is for my web-only accounting system, Quickbooks. Ever since Intuit gave up on a standalone app and went to a web-only solution, I've been accidentally closing my Quickbooks window when I quit my browser or close browser windows. Now, it is in its own browser instance, which runs independently of everything else, and I'm a happy camper.
